Browsing by Author "Adasme, Tatiana"

Now showing items 1-8 of 8

    • Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca(2+) Release Inducing Mitochondrial Fragmentation ... 
      Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco Friz, María Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (MARY ANN LIEBERT INC, 2011-04)
      Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
    • High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and ... 
      Riquelme, Denise; Álvarez, Alvaro; Leal, Nancy; Adasme, Tatiana; Espinoza, Italo; Valdés, Juan Antonio; Troncoso, Natalia; Härtel, Steffen; Hidalgo Tapia, Jorge; Hidalgo Tapia, María Cecilia; Carrasco Friz, María Angélica (2011)
      Neuronal electrical activity increases intracellular Ca2+ concentration and generates reactive oxygen species. Here, we show that high frequency field stimulation of primary hippocampal neurons generated Ca2+ signals with ...
    • IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB 
      Maldonado, Carola; Cea, Paola; Adasme, Tatiana; Collao, Andrés; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-04)
      Hyperosmotic stress stimulates a rapid and pronounced apoptosis in cardiac myocytes which is attenuated by insulin-like growth factor-1 (IGF-1). Because in these cells IGF-1 induces intracellular Ca2+ increase, we assessed ...
    • Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and ... 
      Haeger, Paola; Álvarez, Álvaro; Leal, Nancy; Adasme, Tatiana; Núñez González, Marco; Hidalgo Tapia, María Cecilia (Springer, 2009-08-05)
      Iron is essential for crucial neuronal functions but is also highly toxic in excess. Neurons acquire iron through transferrin receptor-mediated endocytosis and via the divalent metal transporter 1 (DMT1). The N-terminus (1A, ...
    • Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum ... 
      Adasme, Tatiana; Paula-Lima, Andrea; Hidalgo Tapia, María Cecilia (Academic Press, 2015)
      Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels while micromolar ...
    • Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2þ release without affecting endoplasmic reticulum ... 
      Adasme, Tatiana; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia (Elsevier, 2015)
      Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels while micromolar ...
    • Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial ... 
      Adasme, Tatiana; Haeger, Paola; Paula Lima, Andrea; Espinoza, Italo; Casas-Alarcón, M. Mercedes; Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (NATL ACAD SCIENCES, 2011-02-15)
      Ryanodine receptors (RyR)amplify activity-dependent calciuminflux via calcium-induced calcium release. Calcium signals trigger postsynaptic pathways in hippocampal neurons that underlie synaptic plasticity, learning, ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...